Trang: 94
Tập 32, số 9 2022
An outbreak of COVID-19 in Bach Mai Hospital, the Major Tertiary Care Hospital in Hanoi, Vietnam, March 2020: Implications for prevention
Tác giả: Le Thi Quynh Mai, Le Anh Tuan, Vu Thi Bich Diep, Nguyen Cong Khanh, Pham Quang Thai, Duong Duc Hung, Tran Van Giang, H. Rogier van Doorn, Tung Trinh Son, Dang Duc Anh, Matthew Moore, Nguyen Tran Hien
Tóm tắt:
Vietnam experienced an outbreak of COVID-19 at Bach Mai hospital, a major tertiary referral hospital in March 2020.
We describe the findings of the outbreak investigation for the purpose of informing future prevention measures. We
defined hospital - related COVID-19 cases as those that tested positive with SARS-CoV-2 RNA using the polymerase
chain reaction (PCR) test during March 4 - 20, 2020 and had been exposed to the hospital in the 14 days before symptom onset or before a positive PCR. We interviewed all COVID-19 cases on their exposure time and analyzed them for
epidemiologic links. We performed whole - genome sequencing (WGS) among those whose Cycle - Threshold values
were <30. Of 36 COVID-19 cases identified, ages ranged from 21-88 years; 10 (28%) remained asymptomatic. We
identified cases among food-service workers (23, 64%), family members (6, 17%), inpatients (4, 11%), healthcare workers (2, 6%), and household contacts (1, 3%). Fourteen (39%) had spent 14 days in the hospital before diagnosis. We
identified 3 clusters of cases consisting of 3 (2 healthcare workers, 1 household contact, the earliest cases), 7 (neurology
department), and 23 cases (all food-service workers). Of 17 WGS - available strains, 14 had identical sequences; the remaining 3 differed by 1 - 2 nucleotide changes. The introduction of SARS-CoV-2 into the hospital likely occurred at an
outpatient screening clinic, while rapid spread may have been facilitated by food-service workers. To prevent outbreaks
of COVID-19 in healthcare settings, infection prevention and control and routine screening among healthcare workers,
including auxiliary groups such as food - service staff should be strengthened.
Summary:
Từ khóa:
COVID-19; disease outbreaks; outbreak investigation; tertiary hospital; PCR; SARS-CoV-2; Vietnam
DOI: https://doi.org/10.51403/0868-2836/2022/929
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